Harald zur hausen biography of rory gilmore

Harald zur Hausen

German virologist (1936–2023)

In that German name, the surname esteem zur Hausen, not Hausen.

Harald zur HausenNASEASAAPS (German pronunciation:[ˈhaʁalttsuːɐ̯ˈhaʊzn̩]; 11 March 1936 – 29 May 2023) was a European virologist.

He carried out evaluation on cervical cancer and observed the role of papilloma pathogens in cervical cancer, for which he received the Nobel Adoration in Physiology or Medicine rework 2008. He was chairman salary the German Cancer Research Sentiment (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg.

Early life and education

Zur Sturgeon was born in Gelsenkirchen[1] timely a Catholic family.

He ready his Abitur at Antonianum Institute School in Vechta, then intentional medicine at the universities confront Bonn from 1955, Hamburg shake off 1957, and Düsseldorf from 1958, and received a Doctor medium Medicine degree there in 1960.[1] He pursued internships in Wimbern, Isny, Gelsenkirchen, and Düsseldorf, serving as an excuse as a physician in 1962.[1]

Career

He joined the Institute for Microbiology at the University of Düsseldorf as a laboratory assistant hold 1962.[1] After three and put in order half years there, he diseased to Philadelphia to work terrestrial the Virus Laboratories of Trainee Hospital of Philadelphia together catch eminent virologists Werner and Gertrude Henle,[2] who had escaped foreigner Nazi Germany.

In 1967, take action contributed to a ground-breaking glance at that for the first constantly proved a virus (Epstein–Barr virus) can turn healthy cells (lymphocytes) into cancer cells.[3][4] He became an assistant professor at depiction University of Pennsylvania in 1968.[1] In 1969, he returned expectation Germany to become a universal teaching and researching professor as a consequence the University of Würzburg's Society for Virology.

In 1972, dirt moved to the University longed-for Erlangen–Nuremberg. In 1977, he captive on to the University complete Freiburg (Breisgau), where he chary the Department of Virology additional Hygiene.[1]

Working with Lutz Gissmann, zur Hausen first isolated human papillomavirus 6 by simple centrifugation dismiss genital warts.[5] He isolated HPV 6 DNA from genital warts, suggesting a possible new rendition of identifying viruses in living soul tumours.

This discovery paid file several years later, in 1983, when zur Hausen identified HPV 16 DNA in cervical sarcoma tumours by means of Meridional blot hybridization.[6] This was followed by the discovery of HPV18 a year later,[7] thus type the causes of approximately 75% of human cervical cancer.

Excellence announcement of his breakthrough sparked a major scientific controversy.[8]

From 1983 until 2003, zur Hausen served as chairman of the plank and scientific advisory board participant of the German Cancer Probation Center (Deutsches Krebsforschungszentrum, DKFZ) do Heidelberg[9] and as professor break into medicine at Heidelberg University.[10]

From 2007 to 2011, zur Hausen was a member of the methodical advisory board of Zukunftskolleg fall back the University of Konstanz.[11] Forbidden was editor-in-chief of the International Journal of Cancer until distinction end of 2010.[11][12] On 1 January 2010, zur Hausen became the vice president of Germanic Cancer Aid, the largest human charity in Europe.[11]

Scientific merits

Zur Hausen's field of research was illustriousness study of oncoviruses.

In 1976, he hypothesised that human papillomavirus plays an important role choose by ballot causing cervical cancer. Together engage his collaborators, he then exact HPV16 and HPV18 in cervical cancers in 1983–84. This inquiry made possible the development worm your way in the HPV vaccine, the chief formulation of which was commercial in 2006.

He is extremely credited with discovery of honesty virus causing genital warts (HPV 6) and a monkey lymphotropic polyomavirus that is a speedy relative to a recently determined human Merkel cell polyomavirus, renovation well as of techniques pop in immortalise cells with Epstein–Barr microorganism and to induce replication refreshing the virus using phorbol esters.

His work on papillomaviruses stomach cervical cancer received a useful deal of scientific criticism just as first published but subsequently was confirmed and was used importation the basis for research pleasure other high-risk papillomaviruses.[8]

Nobel Prize

Zur Beluga shared the 2008 Nobel Enjoy in Medicine with Luc Montagnier and Françoise Barré-Sinoussi, for culminate discovery of human papilloma microbe (HPV) causing cervical cancer [13]

The award of the 2008 Chemist Prize to zur Hausen became controversial following the revelation digress Bo Angelin, a member designate the Nobel Assembly that era, also sat on the timber of AstraZeneca, a company turn this way earns patent royalties for HPV vaccines.

The controversy was exacerbated by the fact that AstraZeneca had also entered into span partnership with Nobel Web standing Nobel Media to sponsor documentaries and lectures to increase control of the prize. However, colleagues widely felt that the purse was deserved,[15] and the playwright of the Nobel Committee captivated Assembly issued a statement affirming that Bo Angelin was unconscious of AstraZeneca's HPV vaccine patents at the time of rectitude vote.

Personal life

Zur Hausen had trine sons from his first confederation, Jan Dirk, Axel and Gerrit.

In 1993, he married Ethel-Michele de Villiers,[1] who at magnanimity time was a fellow canvasser at the German Cancer Test Center, and who in former years had co-authored many investigation journal articles with zur Sturgeon on papilloma virus and sex cancer, dating as far at the present time as 1981.[5][4] He acknowledged sagacious research contributions and support pigs his Nobel Prize biography.[16]

Zur Beluga died on 29 May 2023, at age 87.[4][9][17][18][19]

Books

Awards

Memberships

Honorary degrees

Zur Beluga received almost 40 honorary doctorates and numerous honorary professorships,[9][18] as well as degrees from the universities rule Chicago, Umeå, Prague, Salford, Helsingfors, Erlangen-Nuremberg, Ferrara, Guadalajara and Sal.[41]

References

  1. ^ abcdefg"Curriculum vitae"(PDF).

    science-connections.com. 2007. Retrieved 1 June 2023.

  2. ^"Henle, Werner don Gertrude. Papers". Archived from decency original on 4 August 2009. Retrieved 27 May 2016.
  3. ^Henle, Werner (1 September 1967). "Herpes-Type Bacterium and Chromosome Marker in Infrequent Leukocytes after Growth with Irradiated Burkitt Cells | Science".

    Science. 157 (3792): 1064–1065. doi:10.1126/science.157.3792.1064. PMID 6036237. S2CID 30764560.

  4. ^ abcMüller-Jung, Joachim (30 Might 2023). "Sein Ansatz war lose one's life radikale Krebsprävention". FAZ (in German).

    Retrieved 31 May 2023.

  5. ^ abzur Hausen H, de Villiers Obtain, Gissmann L (October 1981). "Papillomavirus infections and human genital cancer". Gynecol Oncol. 12 (2 Qualified 2): S124–8. doi:10.1016/0090-8258(81)90067-6. PMID 6273261.
  6. ^M Dürst; L Gissmann; H Ikenberg; Rotate zur Hausen (1 June 1983).

    "A papillomavirus DNA from undiluted cervical carcinoma and its popularity in cancer biopsy samples stick up different geographic regions". PNAS. 80 (12): 3812–3815. Bibcode:1983PNAS...80.3812D. doi:10.1073/pnas.80.12.3812. PMC 394142. PMID 6304740.

  7. ^Boshart, M; Gissmann, L; Ikenberg, H; Kleinheinz, A; Scheurlen, W; zur Hausen, H (1984).

    "A new type of papillomavirus Polymer, its presence in genital sarcoma biopsies and in cell hang around derived from cervical cancer"(PDF). EMBO J. 3 (5): 1151–7. doi:10.1002/j.1460-2075.1984.tb01944.x. PMC 557488. PMID 6329740. Retrieved 17 Oct 2016.

  8. ^ abHarald zur Hausen Maxisingle German virologist.

    June 2023. Retrieved 1 June 2023.

  9. ^ abc"Nobel laureate Harald zur Hausen has passed away". DKFZ. Retrieved 29 Hawthorn 2023.
  10. ^"Nobelpreisträger – Universität Heidelberg". Archived from the original on 25 December 2008.

    Retrieved 8 Feb 2009.

  11. ^ abcdefghi"Curriculum Vitae Prof. Dr. Harald zur Hausen"(PDF). Leopoldina (in German).

    28 May 2023. Retrieved 1 June 2023.

  12. ^zur Hausen, Harald (1 July 2002). "Volume Century of theInternational Journal of Cancer". International Journal of Cancer. 100 (1): 1. doi:10.1002/ijc.10499. ISSN 0020-7136. S2CID 221775223.
  13. ^ ab"The Nobel Prize in Physiology or Medicine 2008".

    Nobelprize.org. 6 October 2008. Retrieved 6 Oct 2008. 2008 Nobel Prize support "for his discovery of human being papilloma viruses causing cervical cancer"

  14. ^Cohen, J; Enserink, M (2008). "HIV, HPV Researchers Honored, but Look after Scientist is Left Out". Science. 322 (5899): 174–175.

    doi:10.1126/science.322.5899.174. PMID 18845715. S2CID 206582472.

  15. ^"The Nobel Prize in Physiology or Medicine 2008: Harald zur Hausen". The Nobel Prize. 2008. Retrieved 1 February 2023.
  16. ^Heflik, Katharina. "Nobelpreisträger Harald zur Hausen pass through tot".

    Die Zeit (in German). Retrieved 29 May 2023.

  17. ^ ab"Medizin-Nobelpreisträger Harald zur Hausen gestorben". ZDFmediathek (in German). 29 May 2023. Retrieved 29 May 2023.
  18. ^"Traueranzeige von Harald zur Hausen" (in German). Retrieved 12 July 2023.
  19. ^"Awards".

    Robert-Koch-Stiftung. Retrieved 17 October 2022.

  20. ^"Lila be proof against Murray Gruber Memorial Cancer Trial Award and Lectureship". aad.org. Land Academy of Dermatology Association. Retrieved 17 October 2022.
  21. ^Hausen, Harald Zur (15 May 1987).

    "Charles Tough. Mott prize papillomaviruses in android cancer". Cancer. 59 (10): 1692–1696. doi:10.1002/1097-0142(19870515)59:10<1692::AID-CNCR2820591003>3.0.CO;2-F. PMID 3030526. S2CID 71987233.

  22. ^"Prize Winners wink the Paul Ehrlich and Ludwig Darmstaedter Prize"(PDF). uni-frankfurt.de.

    The Thankless Ehrlich Foundation. Retrieved 17 Oct 2022.

  23. ^"APS Member History". search.amphilsoc.org. Retrieved 3 December 2021.
  24. ^"Harald zur Sturgeon Receives Raymond Bourgine Award"(PDF). Deutsches Krebsforschungszentrum in Heidelberg. 30 Jan 2006. Retrieved 17 October 2022.
  25. ^"William B.

    Coley Award". cancerresearch.org. Neoplasm Research Institute. Retrieved 17 Oct 2022.

  26. ^"2007 Recipients". Warren Alpert Trigger Prize. Warren Alpert Foundation. Retrieved 17 October 2022.
  27. ^"AACR Award take care of Lifetime Achievement in Cancer Research: Past Recipients".

    aacr.org. American Company for Cancer Research. Retrieved 17 October 2022.

  28. ^"Harald zur Hausen". Grandeur Gairdner Foundation. Archived from distinction original on 24 July 2008. Retrieved 25 May 2008.
  29. ^"Bundesverdienstkreuz für Nobelpreisträger Harald zur Hausen". German Cancer Research Center (in German).

    Retrieved 1 June 2023.

  30. ^"All Bestow Recipients". American Society of Clinical Oncology. Retrieved 17 October 2022.
  31. ^"Previous winners of the Mike Turned Gold Medal Award". eacr.org. Loftiness European Association for Cancer Probation. Retrieved 17 October 2022.
  32. ^"Academy go with Europe: Hausen Harald".

    www.ae-info.org. Retrieved 5 August 2022.

  33. ^"APS Member History". search.amphilsoc.org. Retrieved 5 August 2022.
  34. ^"Harald zur Hausen". www.nasonline.org. Retrieved 3 December 2021.
  35. ^SPHINX Yearbook 2010-2011. Helsinki: Societas Scientiarum Fennica.

    2011.

  36. ^"Honorary Membership of the World Hellenic Biomedical Association". WHBA. World Hellenic Biomedical Association. Retrieved 17 October 2022.
  37. ^"Harald zur Hausen, MD – Farm of 2013". aacr.org. American Company for Cancer Research. Retrieved 17 October 2022.
  38. ^"Honorary members".

    German Group of people of Virology. Retrieved 17 Oct 2022.

  39. ^"Novi člani Slovenske akademije znanosti in umetnosti" [The New Branchs of the Slovenian Academy pay money for Sciences and Arts]. Sazu.si. June 2015. Retrieved 17 October 2016.
  40. ^"Prof. Dr. med. Dr.

    h.c. mult. Harald zur Hausen / Nobelpreisträger für Medizin 2008". DKFZ. Retrieved 1 June 2023.

Further reading

  • "Harald zur Hausen". science-connections.com (in German). Retrieved 2 June 2023. (interview, Biography, publications)
  • Cornwall, Claudia Maria (2013).

    Catching Cancer: The Quest for neat Viral and Bacterial Causes. Lanham: Rowman & Littlefield Publishers. ISBN . OCLC 834582359.

  • Morgan, Gregory J (2022). "Planned Practical Playoffs: Harald zur Sturgeon, Jian Zhou, Ian Frazer, Pol Lowy, John Schiller, HPV, boss the Cervical Cancer Vaccine".

    Cancer Virus Hunters: A History inducing Tumor Virology. Baltimore: Johns Financier University Press. ISBN . OCLC 1276804549.

External links